Article
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2010
Tesli Martin, Athanasiu Lavinia, Mattingsdal Morten, Kähler Anna K, Gustafsson Omar, Andreassen Bettina K, Werge Thomas, Hansen Thomas, Mors Ole, Mellerup Erling, Koefoed Pernille, Jönsson Erik G, Agartz Ingrid, Melle Ingrid, Morken Gunnar, Djurovic Srdjan, Andreassen Ole A
Abstract excerpt
A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and...
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