Article
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
The Prostate - 1 Aug 2009
Kader A Karim, Sun Jielin, Isaacs Sarah D, Wiley Kathleen E, Yan Guifang, Kim Seong-Tae, Fedor Helen, DeMarzo Angelo M, Epstein Jonathan I, Walsh Patrick C, Partin Alan W, Trock Bruce, Zheng S Lilly, Xu Jianfeng, Isaacs William
Abstract excerpt
BACKGROUND: More than a dozen single nucleotide polymorphisms (SNPs) have been associated with prostate cancer (PCa) risk from genome-wide association studies (GWAS). Their association with PCa aggressiveness and clinicopathologic variables is inconclusive. METHODS: Twenty PCa risk SNPs implicated in GWAS and fine mapping studies were evaluated in 5,895 PCa cases treated by radical prostatectomy at Johns Hopkins...
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