Article
Multiple newly identified loci associated with prostate cancer susceptibility.
Nature genetics - 1 Mar 2008
Eeles Rosalind A, Kote-Jarai Zsofia, Giles Graham G, Olama Ali Amin Al, Guy Michelle, Jugurnauth Sarah K, Mulholland Shani, Leongamornlert Daniel A, Edwards Stephen M, Morrison Jonathan, Field Helen I, Southey Melissa C, Severi Gianluca, Donovan Jenny L, Hamdy Freddie C, Dearnaley David P, Muir Kenneth R, Smith Charmaine, Bagnato Melisa, Ardern-Jones Audrey T, Hall Amanda L, O'Brien Lynne T, Gehr-Swain Beatrice N, Wilkinson Rosemary A, Cox Angie, Lewis Sarah, Brown Paul M, Jhavar Sameer G, Tymrakiewicz Malgorzata, Lophatananon Artitaya, Bryant Sarah L, Horwich Alan, Huddart Robert A, Khoo Vincent S, Parker Christopher C, Woodhouse Christopher J, Thompson Alan, Christmas Tim, Ogden Chris, Fisher Cyril, Jamieson Charles, Cooper Colin S, English Dallas R, Hopper John L, Neal David E, Easton Douglas F
Abstract excerpt
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at </=60...
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