Article
Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
Neoplasia (New York, N.Y.) - 1 Apr 2013
Chen Zhuo, Sun Jielin, Kim Seong-Tae, Groskopf Jack, Feng Junjie, Isaacs William B, Rittmaster Roger S, Condreay Lynn D, Zheng Siqun Lilly, Xu Jianfeng
Abstract excerpt
Prostate cancer gene 3 (PCA3) is a non-coding gene specifically overexpressed in prostate cancer (PCa) that has great potential as a clinical biomarker for predicting prostate biopsy outcome. However, genetic determinants of PCA3 expression level remain unknown. To investigate the association between genetic variants and PCA3 mRNA level, a genome-wide association study was conducted in 1371 men of European...
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