Article
CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.
PloS one - 1 Jan 2014
Rihani Ali, De Wilde Bram, Zeka Fjoralba, Laureys Geneviève, Francotte Nadine, Tonini Gian Paolo, Coco Simona, Versteeg Rogier, Noguera Rosa, Schulte Johannes H, Eggert Angelika, Stallings Raymond L, Speleman Frank, Vandesompele Jo, Van Maerken Tom
Abstract excerpt
BACKGROUND: Neuroblastoma is a pediatric cancer that exhibits a wide clinical spectrum ranging from spontaneous regression in low-risk patients to fatal disease in high-risk patients. The identification of single nucleotide polymorphisms (SNPs) may help explain the heterogeneity of neuroblastoma and assist in identifying patients at higher risk for poor survival. SNPs in the TP53 pathway are of special...
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