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Article

A comprehensive study of polymorphisms in<i>ABCB1, ABCC2</i>and<i>ABCG2</i>and lung cancer chemotherapy response and prognosis

3 Apr 2012

Abstract excerpt

ATP-binding cassette (ABC) transporter expression and genetic heterogeneity have been implicated in response to anticancer therapy. This study characterized genetic variability of the ABCB1 (also known as MDR1), ABCC2 (MRP2) and ABCG2 (BCRP) genes, which are key players in the metabolism of many chemotherapeutic agents including those used in the treatment of lung cancer. We genotyped 53 polymorphisms in the...

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PMID: 22473764
DOI: 10.1002/ijc.27567

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