Article
Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
European journal of clinical pharmacology - 1 May 2011
Bellanti Francesco, Kågedal Bertil, Della Pasqua Oscar
Abstract excerpt
PURPOSE: Neuroblastoma is the most common extracranial solid tumour in childhood. It accounts for 15% of all paediatric oncology deaths. In the last few decades, improvement in treatment outcome for high-risk patients has not occurred, with an overall survival rate <30-40%. Many reasons may account for such a low survival rate. The aim of this review is to evaluate whether pharmacogenetic factors can explain...
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