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Article

Diversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergence.

PloS one - 2 Feb 2011

Domingo-Gil Elena, Toribio René, Nájera José Luis, Esteban Mariano, Ventoso Iván

Abstract excerpt

Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a mechanism that requires a stem loop structure in viral 26S mRNA termed DLP to initiate translation in the absence of functional eIF2. Unlike the rest of viruses...

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Identifiers

PMID: 21311764
DOI: 10.1371/journal.pone.0016711
PMCID: PMC3032782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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