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Article

Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest

25 Jun 2024

Abstract excerpt

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in human populations. ZIKV infection leads to the accumulation of small non-coding viral RNAs (known as sfRNAs) that are crucial for evasion of antiviral responses and for viral pathogenesis. However, the mechanistic understanding of how sfRNAs function remains incomplete. Here, we use recombinant ZIKVs and ribosome profiling...

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PMID: 38917323
DOI: 10.1093/nar/gkae507

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