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Balancing acts: The posttranslational modification tightrope of flavivirus replication

28 Oct 2024

Abstract excerpt

Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In...

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PMID: 39466723
DOI: 10.1371/journal.ppat.1012626

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