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Article

An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect.

Virus research - 1 Apr 2011

Tange Shoichiro, Imai Takeshi, Nakanishi Akira

Abstract excerpt

On reexamination of temperature-sensitive D-type (tsD) mutants of simian virus 40 (SV40), we found that the tsD222 mutant is identical to the VP2 M228I mutant, which is defective in VP4 expression, at the nucleotide level. Although a previous study reported that lack of VP4 caused defects in viral dissemination in BSC-1 cells, this mutant showed a temperature-sensitive growth defect in CV-1 cells. tsD101:VP3...

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PMID: 21310196
DOI: 10.1016/j.virusres.2011.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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