Article
Identification of amino acids in Marburg virus VP40 that are important for virus-like particle budding.
The Journal of infectious diseases - 1 Nov 2011
Makino Akiko, Yamayoshi Seiya, Shinya Kyoko, Noda Takeshi, Kawaoka Yoshihiro
Abstract excerpt
The matrix protein VP40 of Marburg virus promotes the formation and release of virus-like particles (VLPs). Marburg virus VP40 interacts with cellular Tsg101 via its L domain motif; however, mutation of this motif does not affect VLP budding or the accumulation of VP40 in multivesicular bodies (MVBs), which are platforms for virus particle formation. To identify regions of Marburg virus VP40 that are important...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
