Article
A structural rationale for SV40 Vp1 temperature-sensitive mutants and their complementation.
Protein science : a publication of the Protein Society - 1 Sept 2006
Kasamatsu Harumi, Woo Jennifer, Nakamura Akiko, Müller Peter, Tevethia M Judith, Liddington Robert C
Abstract excerpt
Two groups of temperature-sensitive (ts) mutants, termed ts B and ts C, have mutations in the major capsid protein of SV40, Vp1. These mutants have virion assembly defects at the nonpermissive temperature, but can complement one another when two mutants, one from each group, coinfect a cell. A third group of mutants, termed ts BC, have related phenotypes, but do not complement other mutants. We found that the...
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