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Article

Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis.

Journal of virology - 1 Feb 1995

Dean D A, Li P P, Lee L M, Kasamatsu H

Abstract excerpt

Both a DNA-binding domain and a Vp1 interactive determinant have been mapped to the carboxy-terminal 40 residues of the simian virus 40 (SV40) minor capsid proteins, Vp2 and Vp3 (Vp2/3), with the last 13 residues being necessary for these activities. The role of this DNA-binding domain in SV40 morphogenesis and the ability to separate these two signals were investigated by mutagenesis and assessment of the...

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Source

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Identifiers

PMID: 7815491
DOI: 10.1128/JVI.69.2.1115-1121.1995
PMCID: PMC188684

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis.PMID 7815491Read ↗

The simian virus 40 minor structural protein Vp3, but not Vp2, is essential for infectious virion formation.Semantic proximity Read ↗

Minor Capsid Proteins of Simian Virus 40 Are Dispensable for Nucleocapsid Assembly and Cell Entry but Are Required for Nuclear Entry of the Viral GenomeSemantic proximity Read ↗

Identification of a DNA binding domain in simian virus 40 capsid proteins Vp2 and Vp3.Semantic proximity Read ↗

Identification of amino acid residues within simian virus 40 capsid proteins Vp1, Vp2, and Vp3 that are required for their interaction and for viral infection.Semantic proximity Read ↗

Simian virus 40 Vp1 DNA-binding domain is functionally separable from the overlapping nuclear localization signal and is required for effective virion formation and full viability.Semantic proximity Read ↗

Role of simian virus 40 Vp1 cysteines in virion infectivity.Semantic proximity Read ↗

Two independent signals, a nuclear localization signal and a Vp1-interactive signal, reside within the carboxy-35 amino acids of SV40 Vp3.Semantic proximity Read ↗

Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.Semantic proximity Read ↗

An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect.Semantic proximity Read ↗

A very late viral protein triggers the lytic release of SV40.Semantic proximity Read ↗

The viroporin activity of the minor structural proteins VP2 and VP3 is required for SV40 propagation.Semantic proximity Read ↗

Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1.Semantic proximity Read ↗

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