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Article

Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis.

Journal of virology - 1 Feb 1995

Dean D A, Li P P, Lee L M, Kasamatsu H

Abstract excerpt

Both a DNA-binding domain and a Vp1 interactive determinant have been mapped to the carboxy-terminal 40 residues of the simian virus 40 (SV40) minor capsid proteins, Vp2 and Vp3 (Vp2/3), with the last 13 residues being necessary for these activities. The role of this DNA-binding domain in SV40 morphogenesis and the ability to separate these two signals were investigated by mutagenesis and assessment of the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Chlorocebus aethiops
DNA
DNA-Binding Proteins
Genome, Viral
Molecular Sequence Data
Morphogenesis
Mutation
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian virus 40

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Identifiers

PMID: 7815491
DOI: 10.1128/JVI.69.2.1115-1121.1995
PMCID: PMC188684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7815491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis.PMID 7815491Read ↗

The simian virus 40 minor structural protein Vp3, but not Vp2, is essential for infectious virion formation.Semantic proximity Read ↗

Minor Capsid Proteins of Simian Virus 40 Are Dispensable for Nucleocapsid Assembly and Cell Entry but Are Required for Nuclear Entry of the Viral GenomeSemantic proximity Read ↗

Identification of a DNA binding domain in simian virus 40 capsid proteins Vp2 and Vp3.Semantic proximity Read ↗

Identification of amino acid residues within simian virus 40 capsid proteins Vp1, Vp2, and Vp3 that are required for their interaction and for viral infection.Semantic proximity Read ↗

Simian virus 40 Vp1 DNA-binding domain is functionally separable from the overlapping nuclear localization signal and is required for effective virion formation and full viability.Semantic proximity Read ↗

Role of simian virus 40 Vp1 cysteines in virion infectivity.Semantic proximity Read ↗

Two independent signals, a nuclear localization signal and a Vp1-interactive signal, reside within the carboxy-35 amino acids of SV40 Vp3.Semantic proximity Read ↗

Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.Semantic proximity Read ↗

An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect.Semantic proximity Read ↗

A very late viral protein triggers the lytic release of SV40.Semantic proximity Read ↗

The viroporin activity of the minor structural proteins VP2 and VP3 is required for SV40 propagation.Semantic proximity Read ↗

Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1.Semantic proximity Read ↗

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