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Article

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

Trends in cell biology - 1 May 2011

Berwick Daniel C, Harvey Kirsten

Abstract excerpt

Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a major cause of Parkinson's disease. We contrast data suggesting that changes in LRRK2 activity cause alterations in mitogen-activated protein kinase, translational control, tumor necrosis factor α/Fas ligand and Wnt signaling pathways with the cell biological functions of LRRK2 such as vesicle trafficking. Despite scarce in vivo data on cell...

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Identifiers

PMID: 21306901
DOI: 10.1016/j.tcb.2011.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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