LRRK2 signaling pathways: the key to unlocking neurodegeneration?

doi:10.1016/j.tcb.2011.01.001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

Trends in cell biology - 1 May 2011

Berwick Daniel C, Harvey Kirsten

Abstract excerpt

Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a major cause of Parkinson's disease. We contrast data suggesting that changes in LRRK2 activity cause alterations in mitogen-activated protein kinase, translational control, tumor necrosis factor α/Fas ligand and Wnt signaling pathways with the cell biological functions of LRRK2 such as vesicle trafficking. Despite scarce in vivo data on cell...

Topics

Animals
Humans
Intracellular Signaling Peptides and Proteins
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases
Protein Structure, Tertiary
Signal Transduction
Tumor Necrosis Factors
Wnt Proteins

Source

Open in PubMed

Identifiers

PMID: 21306901
DOI: 10.1016/j.tcb.2011.01.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics