Article
Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia.
British journal of cancer - 6 Dec 2011
Hou H-A, Kuo Y-Y, Liu C-Y, Lee M C, Tang J-L, Chen C-Y, Chou W-C, Huang C-F, Lee F-Y, Liu M-C, Yao M, Tien H-F
Abstract excerpt
BACKGROUND: Aberrant activation of Wnt signalling through hypermethylation of Wnt inhibitor genes is involved in several human malignancies, including acute myeloid leukaemia (AML). It remains unclear whether hypermethylation of Wnt inhibitors is associated with molecular gene mutations in the development of AML. METHODS: We investigated the association of the promoter hypermethylation of six Wnt inhibitors...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.