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Article

Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas.

International journal of cancer - 1 Jun 2010

Götze Silke, Wolter Marietta, Reifenberger Guido, Müller Oliver, Sievers Sonja

Abstract excerpt

Aberrant activation of wingless (Wnt) signaling is involved in the pathogenesis of various cancers. Recent studies suggested a role of Wnt signaling in gliomas, the most common primary brain tumors. We investigated 70 gliomas of different malignancy grades for promoter hypermethylation in 8 genes encoding members of the secreted frizzled-related protein (SFRP1, SFRP2, SFRP4, SFRP5), dickkopf (DKK1, DKK3) and...

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Source

Identifiers

PMID: 19847810
DOI: 10.1002/ijc.24981

Genes

SFRP1
DKK1
NKD2
CTNNB1
DKK3
NKD1
SFRP2
SFRP5
SFRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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