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Identification of <i>PITX1</i> as a <i>TERT</i> Suppressor Gene Located on Human Chromosome 5

8 Feb 2011

Abstract excerpt

Telomerase, a ribonucleoprotein enzyme that maintains telomere length, is crucial for cellular immortalization and cancer progression. Telomerase activity is attributed primarily to the expression of telomerase reverse transcriptase (TERT). Using microcell-mediated chromosome transfer (MMCT) into the mouse melanoma cell line B16F10, we previously found that human chromosome 5 carries a gene, or genes, that can...

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PMID: 21300782
DOI: 10.1128/mcb.00470-10

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of <i>PITX1</i> as a <i>TERT</i> Suppressor Gene Located on Human Chromosome 5PMID 21300782Read ↗

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTRSemantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

PinX1 the tail on the chromosomeSemantic proximity Read ↗

Understanding and exploiting <i>hTERT</i> promoter regulation for diagnosis and treatment of human cancersSemantic proximity Read ↗

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.Semantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomasSemantic proximity Read ↗

Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.Semantic proximity Read ↗

The <i>Telomerase Reverse Transcriptase</i> (<i>hTERT</i>) Gene Is a Direct Target of the Histone Methyltransferase SMYD3Semantic proximity Read ↗

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