Article
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.
Cell - 17 Jun 2005
Kolfschoten Ingrid G M, van Leeuwen Bart, Berns Katrien, Mullenders Jasper, Beijersbergen Roderick L, Bernards Rene, Voorhoeve P Mathijs, Agami Reuven
Abstract excerpt
Activating mutations of RAS frequently occur in subsets of human cancers, indicating that RAS activation is important for tumorigenesis. However, a large proportion of these cancers still retain wild-type RAS alleles, suggesting that either the RAS pathway is activated in a distinct manner or another pathway is deregulated. To uncover novel tumor-suppressor genes, we screened an RNA-interference library for...
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