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Article

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR

21 Sept 2004

Abstract excerpt

The addition of telomeric repeats to chromosome ends by the enzyme telomerase is a highly orchestrated process. Although much is known regarding telomerase catalytic activity in vitro, less is known about how this activity is regulated in vivo to ensure proper telomere elongation. One protein that appears to be involved in negatively regulating telomerase function in vivo is PinX1 because overexpression of PinX1...

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Share to Advanced biosensing and bioanalysis techniques
Share to Telomeres, Telomerase, and Senescence
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15381700
DOI: 10.1074/jbc.m408131200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTRPMID 15381700Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.Semantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

PinX1 the tail on the chromosomeSemantic proximity Read ↗

Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.Semantic proximity Read ↗

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

Identification of <i>PITX1</i> as a <i>TERT</i> Suppressor Gene Located on Human Chromosome 5Semantic proximity Read ↗

Telomerase Interaction Partners–Insight from PlantsSemantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceSemantic proximity Read ↗

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