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Article

Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.

Biochemical and biophysical research communications - 23 Feb 2007

Lin Jian, Jin Rui, Zhang Bin, Yang Ping Xun, Chen Hao, Bai Yun Xiu, Xie Yuehua, Huang Cuifen, Huang JunJian

Abstract excerpt

The factor PinX1 has been shown as a telomerase inhibitor evolutionarily conserved in both the yeast and the human being. yPinX1 inhibits telomerase activity by sequestering yTERT (telomerase reverse transcriptase) from uniting with yTR (telomerase template RNA) in the nucleolus of yeast cells. However, the mechanism underlying the action of hPinX1 on telomerase regulation in human cells is not known. We here...

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PMID: 17198684
DOI: 10.1016/j.bbrc.2006.12.123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.PMID 17198684Read ↗

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PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

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Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression.Semantic proximity Read ↗

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