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Article

Key Genomic Changes Necessary for an <i>In Vivo</i> Lethal Mouse Marburgvirus Variant Selection Process

3 Feb 2011

Abstract excerpt

Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection. The passage of progenitor (wild-type) MARV or Ravn virus (RAVV) from infected scid BALB/c mouse liver homogenates into immunocompetent BALB/c mice results in the selection of...

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PMID: 21289122
DOI: 10.1128/jvi.02372-10

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