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Article

Genomic differences between guinea pig lethal and nonlethal Marburg virus variants.

The Journal of infectious diseases - 15 Nov 2007

Lofts Loreen L, Ibrahim M Sofi, Negley Diane L, Hevey Michael C, Schmaljohn Alan L

Abstract excerpt

The complete genome sequences of 2 closely related plaque-derived variants of Marburg virus (MARV) species Lake Victoria marburgvirus, strain Musoke, indicate only a few regions of the RNA genome as underlying the differences between the 2 viruses. One variant is >90% lethal for guinea pigs and the other much less virulent, when guinea pigs are challenged with 1000 pfu of virus. Only 4 mutations that result in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17940965
DOI: 10.1086/520585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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