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Article

Direct determination of the point mutation rate of a murine retrovirus.

Journal of virology - 1 Jun 1992

Monk R J, Malik F G, Stokesberry D, Evans L H

Abstract excerpt

The point mutation rate of a murine leukemia virus (MuLV) genome (AKV) was determined under conditions in which the number of replicative cycles was carefully controlled and the point mutation rate was determined by direct examination of the RNA genomes of progeny viruses. A clonal cell line infected at a low multiplicity of infection (2 x 10(-3)) was derived to provide a source of virus with high genetic...

Topics

Animals
Base Sequence
Genetic Variation
Genome, Viral
Leukemia Virus, Murine
Mice
Molecular Sequence Data
Muridae
Mutagenesis
Nucleotide Mapping
Oligonucleotides
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonuclease T1

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1316475
DOI: 10.1128/JVI.66.6.3683-3689.1992
PMCID: PMC241152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1316475-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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