Article
Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.
Journal of virology - 20 Aug 2024
Nelson George W, van Duijn Janine, Yuki Yuko, Pau Maria G, Tomaka Frank, Lavreys Ludo, DeRosa Steven C, McElrath M Juliana, Kirk Gregory D, Michael Nelson L, Haas David W, Deeks Steven G, Wolinsky Steven, Walker Bruce, Barouch Dan H, Stieh Daniel, Carrington Mary
Abstract excerpt
HLA class I variation has the strongest effect genome-wide on outcome after HIV infection, and as such, an understanding of the impact of HLA polymorphism on response to HIV vaccination may inform vaccine design. We sought HLA associations with HIV-directed immunogenicity in the phase 1/2a APPROACH vaccine trial, which tested vaccine regimens containing mosaic inserts in Ad26 and MVA vectors, with or without a...
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