Article
Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
Human molecular genetics - 15 Apr 2011
Del Greco M Fabiola, Pattaro Cristian, Luchner Andreas, Pichler Irene, Winkler Thomas, Hicks Andrew A, Fuchsberger Christian, Franke Andre, Melville Scott A, Peters Annette, Wichmann H Erich, Schreiber Stefan, Heid Iris M, Krawczak Michael, Minelli Cosetta, Wiedermann Christian J, Pramstaller Peter P
Abstract excerpt
High blood concentration of the N-terminal cleavage product of the B-type natriuretic peptide (NT-proBNP) is strongly associated with cardiac dysfunction and is increasingly used for heart failure diagnosis. To identify genetic variants associated with NT-proBNP level, we performed a genome-wide association analysis in 1325 individuals from South Tyrol, Italy, and followed up the most significant results in 1746...
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