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Article

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.

Diabetologia - 1 May 2011

Nielsen T, Sparsø T, Grarup N, Jørgensen T, Pisinger C, Witte D R, Hansen T, Pedersen O

Abstract excerpt

AIMS/HYPOTHESIS: By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead variants of these loci on estimates of insulin release and insulin resistance derived from an oral glucose tolerance test. METHODS: We examined 12 lead variants in or near HMGA2, CENTD2 (also...

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Share to Dual-Specificity Phosphatases
Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 1-alpha

Share to HMGA2 Protein

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Share to KCNQ1 Potassium Channel

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Source

Identifiers

PMID: 21267535
DOI: 10.1007/s00125-011-2054-3

Genes

DUSP9
HMGA2
KCNQ1
KLF14
PRC1
ZBED3
ZFAND6

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