Article
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Circulation. Cardiovascular genetics - 1 Jun 2014
Cornes Belinda K, Brody Jennifer A, Nikpoor Naghmeh, Morrison Alanna C, Chu Huan, Ahn Byung Soo, Wang Shuai, Dauriz Marco, Barzilay Joshua I, Dupuis Josée, Florez Jose C, Coresh Josef, Gibbs Richard A, Kao W H Linda, Liu Ching-Ti, McKnight Barbara, Muzny Donna, Pankow James S, Reid Jeffrey G, White Charles C, Johnson Andrew D, Wong Tien Y, Psaty Bruce M, Boerwinkle Eric, Rotter Jerome I, Siscovick David S, Sladek Robert, Meigs James B
Abstract excerpt
BACKGROUND: Common variation at the 11p11.2 locus, encompassing MADD, ACP2, NR1H3, MYBPC3, and SPI1, has been associated in genome-wide association studies with fasting glucose and insulin (FI). In the Cohorts for Heart and Aging Research in Genomic Epidemiology Targeted Sequencing Study, we sequenced 5 gene regions at 11p11.2 to identify rare, potentially functional variants influencing fasting glucose or FI...
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