The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.

doi:10.1038/s41419-018-0272-z

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Article

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.

Cell death & disease - 15 Feb 2018

Mellado-Gil Jose M, Fuente-Martín Esther, Lorenzo Petra I, Cobo-Vuilleumier Nadia, López-Noriega Livia, Martín-Montalvo Alejandro, Gómez Irene de Gracia Herrera, Ceballos-Chávez Maria, Gómez-Jaramillo Laura, Campos-Caro Antonio, Romero-Zerbo Silvana Y, Rodríguez-Comas Júlia, Servitja Joan-Marc, Rojo-Martinez Gemma, Hmadcha Abdelkrim, Soria Bernat, Bugliani Marco, Marchetti Piero, Bérmudez-Silva Francisco J, Reyes Jose C, Aguilar-Diosdado Manuel, Gauthier Benoit R

Abstract excerpt

HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we demonstrate that HMG20A is expressed in both human and mouse islets and that levels are decreased in...

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PMID: 29449530
DOI: 10.1038/s41419-018-0272-z
PMCID: PMC5833347

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