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Article

Promising noninvasive cellular phenotype in prostate cancer cells knockdown of matrix metalloproteinase 9.

TheScientificWorldJournal - 1 Jan 2013

Gupta Aditi, Cao Wei, Sadashivaiah Kavitha, Chen Wantao, Schneider Abraham, Chellaiah Meenakshi A

Abstract excerpt

Cell surface interaction of CD44 and MMP9 increases migration and invasion of PC3 cells. We show here that stable knockdown of MMP9 in PC3 cells switches CD44 isoform expression from CD44s to CD44v6 which is more glycosylated. These cells showed highly adhesive morphology with extensive cell spreading which is due to the formation of focal adhesions and well organized actin-stress fibers. MMP9 knockdown blocks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23476138
DOI: 10.1155/2013/493689
PMCID: PMC3580924

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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