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Article

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.

Biomolecules - 29 Jan 2021

Bhatt Akshita B, Patel Saloni, Matossian Margarite D, Ucar Deniz A, Miele Lucio, Burow Matthew E, Flaherty Patrick T, Cavanaugh Jane E

Abstract excerpt

Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, and metastases. Activators of ERK5, including mitogen-activated protein kinase 5 (MEK5), tumor necrosis factor α (TNF-α), and transforming growth factor-β (TGF-β), are...

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Identifiers

PMID: 33572742
DOI: 10.3390/biom11020183
PMCID: PMC7911413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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