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Article

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models

1 Oct 2012

Abstract excerpt

Approximately half of prostate cancers (PCa) carry TMPRSS2-ERG translocations; however, the clinical impact of this genomic alteration remains enigmatic. Expression of v-ets erythroblastosis virus E26 oncogene like (avian) gene (ERG) promotes prostatic epithelial dysplasia in transgenic mice and acquisition of epithelial-to-mesenchymal transition (EMT) characteristics in human prostatic epithelial cells (PrECs)....

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PMID: 23027626
DOI: 10.1093/carcin/bgs285

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