Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway

9 Apr 2020

Abstract excerpt

Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification and expression of AR splice variants, demonstrating that AR remains a key therapeutic target in advanced disease. For the first time we show that IKBKE drives AR signalling in advanced PC. Significant inhibition of AR regulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hippo pathway signaling and YAP/TAZ
Share to Prostate Cancer Treatment and Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32324216
DOI: 10.1093/nar/gkaa271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathwayPMID 32324216Read ↗

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6Semantic proximity Read ↗

The Homeobox Transcription Factor NKX3.1 Displays an Oncogenic Role in Castration-Resistant Prostate Cancer CellsSemantic proximity Read ↗

Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancerSemantic proximity Read ↗

AR Signaling and the PI3K Pathway in Prostate CancerSemantic proximity Read ↗

NUAK family kinase 2 is a novel therapeutic target for prostate cancerSemantic proximity Read ↗

Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancerSemantic proximity Read ↗

Therapeutic Targeting of Histone Lysine Demethylase KDM4B Blocks the Growth of Castration-Resistant Prostate CancerSemantic proximity Read ↗

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene NetworksSemantic proximity Read ↗

ERK5 signalling in prostate cancer promotes an invasive phenotype.Semantic proximity Read ↗

CDK19 and CDK8 Mediator kinases drive androgen-independent <i>in vivo</i> growth of castration-resistant prostate cancerSemantic proximity Read ↗

Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancerSemantic proximity Read ↗

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.