Article
New norfloxacin resistance gene in Pseudomonas aeruginosa PAO.
Antimicrobial agents and chemotherapy - 1 Sept 1990
Fukuda H, Hosaka M, Hirai K, Iyobe S
Abstract excerpt
A new type of norfloxacin-resistant mutant of Pseudomonas aeruginosa PAO was isolated. This mutant showed cross resistance to imipenem and chloramphenicol and hypersusceptibility to beta-lactam and aminoglycoside antibiotics. The new norfloxacin resistance gene nfxC was mapped near catA (46 min) on the PAO chromosome. Norfloxacin accumulation was decreased in the nfxC mutant; furthermore, the rate of imipenem...
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