Article
Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.
Journal of bacteriology - 1 Oct 1999
Köhler T, Epp S F, Curty L K, Pechère J C
Abstract excerpt
We investigated the regulation of the MexEF-OprN multidrug efflux system of Pseudomonas aeruginosa, which is overexpressed in nfxC-type mutants and confers resistance to quinolones, chloramphenicol and trimethoprim. Sequencing of the DNA region upstream of the mexEF-oprN operon revealed the presence of an open reading frame (ORF) of 304 amino acids encoding a LysR-type transcriptional activator, termed MexT. By...
Topics
- 4-Quinolones
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- Biological Transport, Active
- Carbapenems
- Chloramphenicol
- Cloning, Molecular
- Drug Resistance, Multiple
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Operon