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Article

Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Mar 1995

Masuda N, Sakagawa E, Ohya S

Abstract excerpt

Three types of multiple-drug-resistant mutants which were phenotypically similar to previously described nalB, nfxB, and nfxC mutants were isolated from Pseudomonas aeruginosa PAO1 and two clinical isolates. Type 1 (nalB-type) mutants showed cross-resistance to meropenem, cephems, and quinolones. They overproduced an outer membrane protein with an apparent molecular mass of 50 kDa (OprM). Type 2 (nfxB-type)...

Topics

Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Carbapenems
Drug Resistance, Multiple
Electrophoresis, Polyacrylamide Gel
Humans
Microbial Sensitivity Tests
Molecular Weight
Phenotype
Pseudomonas Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudomonas aeruginosa

Salicylates

Salicylic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7793866
DOI: 10.1128/AAC.39.3.645
PMCID: PMC162598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7793866-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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