Article
The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms.
Alzheimer's research & therapy - 19 May 2016
Limon-Sztencel Anna, Lipska-Ziętkiewicz Beata S, Chmara Magdalena, Wasag Bartosz, Bidzan Leszek, Godlewska Beata R, Limon Janusz
Abstract excerpt
BACKGROUND: Over the past two decades, the APOE gene and its polymorphisms have been among the most studied risk factors of Alzheimer disease (AD) development; yet, there are discrepancies between various studies regarding their impact. For this reason, the evaluation of the APOE genotype has not been included in the current European Federation of Neurological Societies guidelines for AD diagnosis and management....
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