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Article

Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS.

Genetic epidemiology - 1 Feb 2011

Shi Gang, Boerwinkle Eric, Morrison Alanna C, Gu C Charles, Chakravarti Aravinda, Rao D C

Abstract excerpt

We propose a two-stage approach to analyze genome-wide association data in order to identify a set of promising single-nucleotide polymorphisms (SNPs). In stage one, we select a list of top signals from single SNP analyses by controlling false discovery rate. In stage two, we use the least absolute shrinkage and selection operator (LASSO) regression to reduce false positives. The proposed approach was evaluated...

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Identifiers

PMID: 21254218
DOI: 10.1002/gepi.20556
PMCID: PMC3624896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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