Article
Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.
PloS one - 17 Dec 2010
Hain Daniel, Bettencourt Brian R, Okamura Katsutomo, Csorba Tibor, Meyer Wibke, Jin Zhigang, Biggerstaff Jason, Siomi Haruhiko, Hutvagner Gyorgy, Lai Eric C, Welte Michael, Müller H-Arno J
Abstract excerpt
The Drosophila argonaute2 (ago2) gene plays a major role in siRNA mediated RNA silencing pathways. Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple copies of glutamine-rich repeats (GRRs). We report here that the ago2 loc...
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