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Article

Monoallelic knockout of r2d2 affects the antiviral RNAi response to Mayaro virus and the reproductive potential in Aedes aegypti.

Parasites & vectors - 1 Feb 2026

Speth Zachary J, Pokhrel Vivek, Featherston Kyah M, Rehard David G, Reid William R, Franz Alexander W E

Abstract excerpt

BACKGROUND: Aedes aegypti is an important vector for several human-pathogenic arboviruses. RNAi is the principal antiviral immune pathway in mosquitoes. Key steps of antiviral RNAi are processing of long dsRNAs into siRNA duplexes by dicer-2; loading of the siRNA duplexes onto Argonaute-2 with the help of R2D2; RISC formation via incorporation of Argonaute-2, which contains an siRNA; RISC-mediated targeting and...

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Identifiers

PMID: 41622198
DOI: 10.1186/s13071-026-07265-9
PMCID: PMC12954946

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