Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference.

Genetics - 1 Mar 2006

Ji Yingbiao, Clark Denise V

Abstract excerpt

PRAT (phosphoribosylamidotransferase; E.C. 2.4.2.14) catalyzes the first reaction in de novo purine nucleotide biosynthesis. In Drosophila melanogaster, the Prat and Prat2 genes are both highly conserved with PRAT sequences from prokaryotes and eukaryotes. However, Prat2 organization and expression during development is different from Prat. We used RNA interference (RNAi) to knock down expression of both Prat and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila Proteins
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Morphogenesis

Share to Purines

Share to Repetitive Sequences, Nucleic Acid

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 16322507
DOI: 10.1534/genetics.105.045641
PMCID: PMC1456287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference.PMID 16322507Read ↗

Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis.Semantic proximity Read ↗

Drosophila melanogaster Prat, a purine de novo synthesis gene, has a pleiotropic maternal-effect phenotype.Semantic proximity Read ↗

Modifiers of Prat, a de novo purine synthesis gene, in Drosophila melanogaster.Semantic proximity Read ↗

A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.Semantic proximity Read ↗

Identification of trf2 mutants of Drosophila with defects in anterior spiracle eversion.Semantic proximity Read ↗

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in <i>Drosophila</i>Semantic proximity Read ↗

Mutation in THO2, a component of THO/TREX complex, causes transcriptional gene silencing and genome-wide DNA methylation changes.Semantic proximity Read ↗

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.Semantic proximity Read ↗

The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease.Semantic proximity Read ↗

Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor.Semantic proximity Read ↗

Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products.Semantic proximity Read ↗

Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.