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Article

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores.

The Journal of cell biology - 30 Mar 2015

Moudgil Devinderjit K, Westcott Nathan, Famulski Jakub K, Patel Kinjal, Macdonald Dawn, Hang Howard, Chan Gordon K T

Abstract excerpt

Kinetochore (KT) localization of mitotic checkpoint proteins is essential for their function during mitosis. hSpindly KT localization is dependent on the RZZ complex and hSpindly recruits the dynein-dynactin complex to KTs during mitosis, but the mechanism of hSpindly KT recruitment is unknown. Through domain-mapping studies we characterized the KT localization domain of hSpindly and discovered it undergoes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25825516
DOI: 10.1083/jcb.201412085
PMCID: PMC4384735

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