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Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease

24 Dec 2018

Abstract excerpt

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. The etiology involves a combination of genetic and environmental factors resulting in abnormal immune responses to intestinal microbiota. Genetic studies have strongly linked genes involved in autophagy to CD, and genes involved in the unfolded...

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PMID: 30590697
DOI: 10.1093/ibd/izy380

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