Article
NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.
European journal of immunology - 1 Mar 2014
Krljanac Branislav, Weih Debra, Jacobsen Ilse D, Hu Desheng, Koliesnik Ievgen, Reppe Katrin, Witzenrath Martin, Weih Falk
Abstract excerpt
Formation of the splenic marginal zone (MZ) depends on the alternative NF-κB signaling pathway. Recently, we reported that unrestricted activation of this pathway in NF-κB2/p100-deficient (p100(-/-) ) knock-in mice alters the phenotype of MZ stroma and B cells. Here, we show that lack of the p100 inhibitor resulted in an expansion of both MZ B and peritoneal B-1 cells. However, these cells failed to generate...
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