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Article

Autoreactive B cells in SLE, villains or innocent bystanders?

21 Oct 2019

Abstract excerpt

The current concepts for development of autoreactive B cells in SLE (systemic lupus erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss. Traditionally, major tolerance loss pathways are thought to be regulated by factors outside the B cell including autoantigen engagement of the B-cell receptor (BCR) with simultaneous type I interferon (IFN) produced by dendritic cells,...

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PMID: 31631359
DOI: 10.1111/imr.12815

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