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Article

Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops.

The Journal of biological chemistry - 3 Dec 2004

Kukkonen Anu, Peräkylä Mikael, Akerman Karl E O, Näsman Johnny

Abstract excerpt

Muscarinic toxin 7 (MT7) is a mamba venom protein antagonist with extremely high selectivity for the M1 muscarinic acetylcholine receptor. To map the sites for the interaction of MT7 with muscarinic receptors we have used chimeric M1:M3 receptors and site-directed mutagenesis of the M3 and M4 receptor subtypes. Two Glu residues in M1, one in extracellular loop 2 and one in extracellular loop 3, were found to be...

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PMID: 15452105
DOI: 10.1074/jbc.M406424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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