Article
Identification and characterization of a loss-of-function human MPYS variant.
Genes and immunity - 1 Jun 2011
Jin L, Xu L-G, Yang I V, Davidson E J, Schwartz D A, Wurfel M M, Cambier J C
Abstract excerpt
MPYS, also known as STING and MITA, is an interferon (IFN)β stimulator essential for host defense against RNA, DNA viruses and intracellular bacteria. MPYS also facilitates the adjuvant activity of DNA vaccines. Here, we report identification of a distinct human MPYS haplotype that contains three non-synonymous single nucleotide polymorphisms (SNPs), R71H-G230A-R293Q (thus, named the HAQ haplotype). We estimate,...
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