Article

A common human <i>MLKL</i> polymorphism confers resistance to negative regulation by phosphorylation

2022-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL , the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. We show that this substitution confers a gain in necroptotic function in human cells, with more rapid accumulation of activated MLKL S132P in biological membranes and MLKL S132P overriding pharmacological...

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Literature Corpus work: 4411e365-e2a4-56a2-a44b-38dd9f56aa37
DOI: 10.1101/2022.09.08.507056

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