Article
Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2016
Surpris Guy, Chan Jennie, Thompson Mikayla, Ilyukha Vladimir, Liu Beiyun C, Atianand Maninjay, Sharma Shruti, Volkova Tatyana, Smirnova Irina, Fitzgerald Katherine A, Poltorak Alexander
Abstract excerpt
With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigation. In this article, we identify novel mutations in NTD of Sting of the MOLF strain in response to HSV and Listeria monocytogenes both in vitro and in vivo. These mutations are responsible for low levels of IFN-β caused by failure of MOLF STING...
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