Article

Humans homozygous for rare or common hypomorphic <i>IL23R</i> variants are prone to tuberculosis

2026-03-25

Abstract excerpt

Homozygosity for rare loss-of-function IL23R variants abolishes IL-23–dependent IFN-γ production by lymphocytes, including NK and innate-like T cells, thereby underlying clinical disease due to weakly virulent mycobacterial species. We report selective enrichment in homozygosity for four hypomorphic IL23R variants in our cohort of patients with tuberculosis. Three of these IL23R alleles are rare (G300V, G149R,...

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Literature Corpus work: fbbfd975-6a99-54ef-a9ce-8a01d1d7da0d
DOI: 10.64898/2026.03.23.713554

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